Journal
NEUROBIOLOGY OF AGING
Volume 32, Issue 5, Pages 966-967Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.05.014
Keywords
Amyotrophic lateral sclerosis; Genome-wide association study; Polymorphism; Dipeptidyl-peptidase 6 (DPP6) gene
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Funding
- Medical Research Council [G0500289, G0500289B, G0900688] Funding Source: researchfish
- MRC [G0500289, G0900688] Funding Source: UKRI
- Medical Research Council [G0900688, G0500289] Funding Source: Medline
- Wellcome Trust [089701] Funding Source: Medline
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We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts. (C) 2009 Elsevier Inc. All rights reserved.
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