Journal
NEUROBIOLOGY OF AGING
Volume 32, Issue 1, Pages 151-156Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.01.014
Keywords
Aging; beta-Amyloid; Neurodegeneration; Environment; Neocortex; Rhesus monkey; Synapse density; Synaptophysin
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Funding
- NIH [AG10435]
- California Regional Primate Research Center [RR00169]
- Shiley Family Foundation
- NATIONAL CENTER FOR RESEARCH RESOURCES [P51RR000169] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG010435] Funding Source: NIH RePORTER
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Environment influences brain development, neurogenesis and, possibly, vulnerability to neurodegenerative disease. We retrospectively examined the brains of aged rhesus monkeys reared during early life in either small cages or larger, standard-sized cages; all monkeys were subsequently maintained in standard-sized cages during adulthood. Aged monkeys reared in smaller cages exhibited significantly greater beta-amyloid plaque deposition in the neocortex and a significant reduction in synaptophysin immunolabeling in cortical regions compared to aged monkeys reared in standard-sized cages (p < 0.001 and p < 0.05, respectively). These findings suggest that early environment may influence brain structure and vulnerability to neurodegenerative changes in late life. Published by Elsevier Inc.
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