Journal
NEUROBIOLOGY OF AGING
Volume 32, Issue 8, Pages 1443-1451Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.09.004
Keywords
Alzheimer disease; Replication; Association studies
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Alzheimer's disease is a genetically complex disorder, for which new putative susceptibility gene are constantly proposed in the literature. We selected 16 candidate genes involved in biological pathways closely related to the pathology, and for which a genetic association with Alzheimer's disease was previously detected: ACE, BACE1, BDNF, ECE1, HSPG2, IDE, IL1a, IL6, IL10, MAPT, PLAU, PrnP, PSEN1, SORL1, TFCP2 and TGFb1. The variants originally associated with the disease were genotyped in a French Caucasian sample including 428 cases and 475 controls and tested for association in order to replicate the initial results. Despite a careful replication study design, we failed to validate the initial findings for any of these variants, with the possible exception of MAPT, SORL1 and TFCP2 for which some nominal but inconsistent evidence of association was observed. (C) 2009 Elsevier Inc. All rights reserved.
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