Journal
NEUROBIOLOGY OF AGING
Volume 32, Issue 6, Pages 1149-1156Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.05.022
Keywords
Adult neurogenesis; Dentate gyrus; Septal; Temporal; Dorsal; Ventral; Fos; Immediate-early gene; Aging; Spatial; Water maze; Stress; Anxiety
Categories
Funding
- Ontario Graduate Scholarship
- Canadian Institutes of Health Research
- National Institute of Mental Health [Z01-MH002784]
Ask authors/readers for more resources
Recent studies suggest that hippocampal function is partially dissociable along its septo-temporal axis: the septal hippocampus is more critical for spatial processing, while the temporal hippocampus may be more important for non-spatial-related behavior. In young adults, water maze training specifically activates new neurons in the temporal hippocampus, but it is unknown whether subregional differences are maintained in older animals, which have reduced neurogenesis levels. We therefore examined gradients of activity-related Fos expression and neurogenesis in 13-month-old rats and found that neurogenesis occurs relatively evenly throughout the dentate gyrus. Water maze experience significantly increased Fos expression in the suprapyramidal blade and Foswas highest in the septal pole of the dentate gyrus whether the animal learned a platform location, swam in the absence of a platform or remained in their cage. No Fos+ young neurons were found using typical markers of immature neurons. However, Fos expression in the subgranular zone, where adult-born neurons predominate, was disproportionally high in the temporal dentate gyrus. These findings indicate that adult-born neurons in the temporal hippocampus are preferentially activated compared with older neurons. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available