Journal
NEUROBIOLOGY OF AGING
Volume 31, Issue 10, Pages 1831-1833Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.09.015
Keywords
Cognitive function; APOE; Age; Alzheimer's disease; Genetic analysis
Categories
Funding
- Netherlands Organization for Scientific Research (NWO) [91203014]
- Russian Foundation for Basic Research (NWO-RFBR) [047.017.043]
- Center of Medical Systems Biology (CMSB)
- Hersenstichting Nederland
- Internationale Stichting Alzheimer Onderzoek (ISAO)
- Alzheimer Association [04516]
- Hersenstichting Nederland [12F04(2).76]
- Interuniversity Attraction Poles (IUAP)
Ask authors/readers for more resources
The E4 allele of the apolipoprotein E gene (APOE) is a well-established determinant of Alzheimer's disease but its relation to cognitive function is much less understood. We studied the age-specific effects of the APOE*E4 allele on cognitive function and cardiovascular risk factors in 2208 related individuals. APOE*E4 allele was significantly associated with reduced test scores for Adult Verbal Learning Test, particularly on the memory and learning sub domains, in persons older than 50 years of age. The effect of APOE*E4 was independent of the effect of APOE*E4 on vascular risk factors and most pronounced on learning ability. Our findings suggest that APOE*E4 has an effect on cognitive function predominantly in the elderly, independent of vascular risk factors. Crown Copyright (C) 2008 Published by Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available