Journal
NEUROBIOLOGY OF AGING
Volume 31, Issue 9, Pages 1495-1502Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.08.023
Keywords
Alzheimer; LTP; Transgenic mouse model; Insulin; Synaptic plasticity; Synaptic transmission; Hippocampus; Growth factor
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Funding
- Alzheimer Research Trust, UK
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Type 2 diabetes has been identified as a risk factor for Alzheimer's disease (AD) This is most likely due to the desensitisation of insulin receptors in the brain. Insulin acts as a growth factor and supports neuronal repair, dendritic sprouting, and differentiation This review discusses the potential role that insulin-like hormones could play in ameliorating the reduced growth factor signalling in the brains of people with AD The incretins glucagon-like peptide-I (GLP-I) and glucose-dependent insulinotropic polypeptide (GIP) have very similar properties in protecting neurons from toxic effects, and are capable of reversing the detrimental effects that beta-amyloid fragments have on synaptic plasticity. Therefore, incretins show great promise as a novel treatment for reducing degenerative processes in AD (C) 2008 Elsevier Inc All rights reserved
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