Journal
NEUROBIOLOGY OF AGING
Volume 31, Issue 12, Pages 2038-2046Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.12.010
Keywords
Alzheimer's disease; Cerebral blood volume; Cerebral blood flow; VASO; MRI; Tissue integrity
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Funding
- Alzheimer Association NIRG [05-14056]
- NIH [R21 NS054916, P30 AG12300]
- Texas Instruments Foundation
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A vascular component is increasingly recognized as important in Alzheimer's disease (AD). We measured cerebral blood volume (CBV) in patients with probable AD or Mild Cognitive Impairment (MCI) and in elderly non-demented subjects using a recently developed Vascular-Space-Occupancy (VASO) MRI technique. While both gray and white matters were examined, significant CBV deficit regions were primarily located in white matter, specifically in frontal and parietal lobes, in which CBV was reduced by 20% in the AD/MCI group. The regions with CBV deficit also showed reduced tissue structural integrity as indicated by increased apparent diffusion coefficients, whereas in regions without CBV deficits no such correlation was found. Subjects with lower CBV tended to have more white matter lesions in FLAIR MRI images and showed slower psychomotor speed. These data suggest that the vascular contribution in AD is primarily localized to frontal/parietal white matter and is associated with brain tissue integrity. (C) 2008 Elsevier Inc. All rights reserved.
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