Journal
NEUROBIOLOGY OF AGING
Volume 31, Issue 10, Pages 1758-1765Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.10.001
Keywords
SHBG; Estradiol; Testosterone; Alzheimer's disease; Dementia
Categories
Funding
- National Institutes of Health [AG07232, RR00645]
- Blanchette Hooker Rockefeller Foundation
- New York City Council Speaker's fund for Public Health Research
- Netherlands Organization for Scientific Research (NWO) [S92-254]
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It has been suggested that low levels of estradiol and testosterone increase dementia risk. However, results of the existing observational studies examining associations of endogenous sex hormones with cognition and dementia are conflicting. A possible explanation for these inconsistent findings could be the involvement of sex hormone-binding globulin (SHBG) in regulating sex hormone levels. In the present study, we examined whether SHBG levels were associated with development of AD and overall dementia in a cohort of elderly men and women free of dementia at baseline. We observed that in both men and women higher levels of SHBG were associated with an increased risk for AD and overall dementia. These results were independent of vascular risk factors and bioactive hormone levels. Whether SHBG is causally related to dementia or whether it is a surrogate marker for rate of biological aging and increased risk or for preclinical stage of dementia has to be elucidated. (C) 2008 Elsevier Inc. All rights reserved.
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