Journal
NEUROBIOLOGY OF AGING
Volume 30, Issue 1, Pages 147-151Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2007.05.016
Keywords
Putamen; Gender; Aging; Voxel-based morphometry
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Funding
- Fond Kommission fur Klinische Forschung (KKF) [766160]
- Klinikum rechts der Isar. Technische Universitat Munchen
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Age-related strucutral brain changes have been demonstrated repeatedly hut data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; age range, 29-80 years) focusing on differential aging between men and women (i.e., interaction of age and gender). Compared to women, men showed accelerated age-related gray matter (GM) loss in the posterior putamen. Our data may constitute the structural substrate for age-related differences in motor function however men and women such as the higher incidence and earlier onset of Parkinson's disease in men. (C) 2007 Elsevier Inc. All rights reserved.
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