Journal
NEUROBIOLOGY OF AGING
Volume 30, Issue 8, Pages 1329-1331Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2007.11.002
Keywords
TDP-43; TARDBP; Frontotemporal dementia; Amyotrophic lateral sclerosis; Genetics
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Funding
- Special Research Fund of the University of Antwerp
- Fund for Scientific Research Flanders (FWO-F)
- Institute for Science and Technology - Flanders (IWT-F)
- Interuniversity Attraction Poles program (IUAP) [P6/43]
- Belgian Science Policy Office
- Stichting Alzheimer Onderzoek (SAO) and a Zenith award of the Alzheimer's Association USA
- Medical Research Foundation Antwerp and Neurosearch Antwerp
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The nuclear TAR DNA binding protein (TDP-43) is deposited in ubiquitin-positive inclusions in frontotemporal dementia (FTD) and annyotrophic lateral sclerosis (ALS), two clinicopathologically overlapping neurodegenerative diseases. In this study we excluded mutations and copy number variations in the gene encoding TDP-43 (TARDBP) from an extended series of 173 FTD and 237 ALS patients. Further, we did Dot identify association of common genetic variants in these patients. Our data implicate that TDP-43 has no primary genetic role in the pathophysiological mechanisms underlying central nervous system neurodegeneration in these diseases. (C) 2007 Elsevier Inc. All rights reserved.
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