Journal
NEUROBIOLOGY OF AGING
Volume 30, Issue 12, Pages 2043-2052Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.02.005
Keywords
Semantic memory; Perirhinal cortex; Semantic dementia; Frontotemporal dementia; Motor neuron disease
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Funding
- Wellcome Trust (Clinical Training Fellowship)
- Sackler Foundation
- Medical Research Council [G9724461] Funding Source: researchfish
- MRC [G9724461] Funding Source: UKRI
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Semantic dementia (SD) is a syndrome of progressive impairment in semantic memory. Fifty-eight brain regions were measured in seven post mortem SD cases, ten normal controls and two disease controls (diagnosis frontotemporal dementia and motor neuron disease, FTD-MND). Manual segmentation of the whole brain has not previously been undertaken in a series of SD cases, either post mortem or during life Widespread volume loss relative to controls was found in SD, with anterior temporal lobe regions bearing the brunt (>60% atrophy of temporopolar and perirhinal cortices bilaterally). Comparison of regional volumes in SD and FTD-MND found greater atrophy in SD only in temporopolar and perirhinal Volumes The sole region showing atrophy relative to controls in FTD-MND but not SD was motor cortex Posterior temporal and frontal regions were not consistently affected and no significant asymmetry of atrophy was found. In summary, whole-brain regional evaluation in SD, in comparison with normal controls and FTD-MND, found anterior temporal atrophy encompassing the perirhinal cortex with relative sparing of adjacent posterior temporal regions. (C) 2008 Elsevier Inc. All rights reserved
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