Journal
NEUROBIOLOGY OF AGING
Volume 29, Issue 12, Pages 1859-1863Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2007.04.027
Keywords
Frontotemporal dementia; Voxel-based morphometry; Stereotypy; Striatum; MRI
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Funding
- NIH Roadmap Multidisciplinary Clinical Research Career Development Award [(K12/NICHD)-HD49078]
- National Institute on Aging [P50 AG16574, U01 AG06786, R01 AG11379, R01 AG15866]
- Mayo Foundation, U.S.A
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Stereotypies are common in frontotemporal lobar degeneration (FTLD) however the anatomical correlates of stereotypies are unknown. We therefore set out to compare patterns of grey matter volume loss in FTLD subjects with and without stereotypies. Subjects with a diagnosis of FTLD that met international consensus criteria were prospectively recruited and separated into those with and without stereotypies. MRI and cognitive measures were obtained and voxel-based morphometry was used to assess the patterns of grey matter volume loss in those with and without stereotypies, compared to a group of age- and gender-matched controls. Demographic and clinical features were similar between subjects with and without stereotypies. FTLD subjects with stereotypies had greater volume loss in the striatum compared to those without stereotypies. Those without stereotypies showed a more widespread and typical pattern of cortical frontotemporal loss. Stereotypies in FTLD are therefore associated with a greater proportion of striatal to cortical! volume loss than those without stereotypies. (c) 2007 Elsevier Inc. All rights reserved.
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