Journal
NEUROBIOLOGY OF AGING
Volume 29, Issue 10, Pages 1587-1590Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2007.03.008
Keywords
Alzheimer's disease; vascular disease; neuropathology; community sample
Categories
Funding
- National Institute on Aging
- National Institutes of Health [NIA U01 AG 19349-01, 5 RO1 AG017155-04]
- Sparks M. Matsunaga Veterans Affairs Medical Center
- NIA
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An increasing number of studies suggest a vascular contribution to Alzheimer's disease (AD). One major question these findings raise is whether vascular disease enhances the formation of AD-like lesions, or whether vascular disease just adds to clinical severity. We examined this question in a fully characterized autopsy sample based oil the Honolulu Asia Aging Study. We found that AD markers of neurodegeneration (amyloid plaques, cerebral amyloid angiopathy and neurofibrillary tangles) were no more prevalent in those with neuropathologically defined vascular lesions compared to those without lesions. Our study suggests the burden of vascular and AD type lesions are independent of each other, and are consistent with an additive effect of the two types of lesions oil cognitive impairment. (C) 2007 Elsevier Inc. All rights reserved.
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