Journal
NEUROBIOLOGY OF AGING
Volume 29, Issue 4, Pages 614-621Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2006.11.002
Keywords
aging; behavior; CCR5; gp 120; HAD; HIV-1; inflammatory cytokines; mice
Categories
Funding
- NIA NIH HHS [R01 AG016710, R01 AG023580, R01 AG016710-07, AG16710, R01 AG023580-04] Funding Source: Medline
- NIMH NIH HHS [MH069148, R01 MH069148-05, R01 MH069148] Funding Source: Medline
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The number of older adults with HIV-1 disease is increasing but little is known about how age influences behavioral deficits associated with HIV-1 infection. The purpose of this study was to determine in a murine model if aging influenced sickness behavior following central injection of HIV-1 gp 120. In initial studies, behavioral deficits induced by acute and repeated intracerebroventricular (ICV) injection of gp 120 were greater in aged mice than in adults. Furthermore, repeated ICV injection of 120 increased hippocampal levels of IL-1 beta and IL-6 mRNA in aged mice but not in adults. To determine if IL-6, which is elevated in aged brain, affects expression of the gp120-binding target, CCR5, microglia (BV-2 cell line) were incubated with increasing concentrations of IL-6. Cell surface expression of CCR5 was increased by IL-6 in a dose-dependent manner. Additionally, IL-6 increased gp 120-dependent chemotaxis. These results suggest that aging increases the sensitivity of mice to behavioral deficits caused by ICV gp120, perhaps by increasing expression of CCR5 and augmenting production of cytokines. (C) 2006 Elsevier Inc. All rights reserved.
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