Journal
NEURO-ONCOLOGY
Volume 16, Issue 12, Pages 1575-1584Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/nou147
Keywords
glioblastoma; invasion; proliferation; targeted therapy
Categories
Funding
- American Brain Tumor Association [2013]
- Steven M. Coffman Charitable Fund
- Jay and Betty Van Andel Foundation
- NIH/NCI [R01 CA123451, U01CA168397]
- Fund for Medical Research and Education, Wayne State University School of Medicine
- Strategic Research Initiative grant, Karmanos Cancer Institute
- Ben and Catherine Ivy Foundation
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Glioblastoma is one of the most devastating cancers, in which tumor cell infiltration into surrounding normal brain tissue confounds clinical management. This review describes basic and translational research into glioma proliferation and invasion, in particular the phenotypic switch underlying a stochastic go or grow model of tumor cell behavior. We include recent progress in system genomics, cancer stem cell theory, and tumor-microenvironment interaction, from which novel therapeutic strategies may emerge for managing this malignant disease. We suggest that an effective therapeutic strategy should target both adaptive glioblastoma cells and the stroma-tumor interaction.
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