Journal
NEURO-ONCOLOGY
Volume 14, Issue 8, Pages 979-993Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/nos135
Keywords
animal models; brain tumor development
Categories
Funding
- Norwegian Cancer Society
- Norwegian Research Council, Innovest AS, Strategic Research Programme, Helse-Vest, Haukeland University Hospital
- Bergen Translational Research Program
- Fonds National de la Recherche (FNR) of Luxembourg
- Centre de Recherche Public de la Sante Luxembourg
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Animal modeling for primary brain tumors has undergone constant development over the last 60 years, and significant improvements have been made recently with the establishment of highly invasive glioblastoma models. In this review we discuss the advantages and pitfalls of model development, focusing on chemically induced models, various xenogeneic grafts of human cell lines, including stem celllike cell lines and biopsy spheroids. We then discuss the development of numerous genetically engineered models available to study mechanisms of tumor initiation and progression. At present it is clear that none of the current animal models fully reflects human gliomas. Yet, the various model systems have provided important insight into specific mechanisms of tumor development. In particular, it is anticipated that a combined comprehensive knowledge of the various models currently available will provide important new knowledge on target identification and the validation and development of new therapeutic strategies.
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