Journal
NEURO-ONCOLOGY
Volume 12, Issue 9, Pages 1004-1008Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/noq034
Keywords
biomarker; blood; glioma; neurooncology
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Funding
- Biosite and Inverness Medical Company (Waltham, MA, USA)
- Nadine Zielonke (Austrian National Cancer Registry)
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We detected distinct plasma concentration profiles of S100B, neuropeptide Y, and secretagogin in 3 of 191 patients enrolled in a previous study investigating brain-tissue-related markers in the blood of patients with atrial fibrillation. Intriguingly, 2 of these 3 patients, both of whom were without neurological symptoms at the time of blood sampling, were diagnosed with malignant glioma (MG) approximately 1 year later. To our knowledge, this is the first report indicating that distinct blood biomarker profiles may be detected long before clinical manifestation of MG.
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