Journal
NEURO-ONCOLOGY
Volume 11, Issue 6, Pages 861-870Publisher
OXFORD UNIV PRESS INC
DOI: 10.1215/15228517-2009-024
Keywords
alpha(v)beta(3); [F-18]Galacto-RGD; malignant glioma; PET; integrins
Categories
Funding
- Faculty of Medicine of the Ludwig-Maximilians-Universitat Munchen [377]
- Deutsche Forschungsgemeinschaft [FOR-411]
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Inhibitors targeting the integrin alpha(v)beta(3) are promising new agents currently tested in clinical trials for supplemental therapy of glioblastoma multiforme (GBM). The aim of our study was to evaluate F-18-labeled glycosylated Arg-Gly-Asp peptide ([F-18]Galacto-RGD) PET for noninvasive imaging of alpha(v)beta(3) expression in patients with GBM, suggesting eligibility for this kind of additional treatment. Patients with suspected or recurrent GBM were examined with [F-18]Galacto-RGD PET. Standardized uptake values (SUVs) of tumor hotspots, galea, and blood pool were derived by region-of-interest analysis. [F-18]Galacto-RGD PET images were fused with cranial MR images for image-guided surgery. Tumor samples taken from areas with intense tracer accumulation in the [F-18]Galacto-RGD PET images and were analyzed histologically and immunohistochemically for alpha(v)beta(3) integrin expression. While normal brain tissue did not show significant tracer accumulation (mean SUV, 0.09 +/- 0.04), GBMs demonstrated significant but heterogeneous tracer uptake, with a maximum in the highly proliferating and infiltrating areas of tumors (mean SUV, 1.6 +/- 0.5). Immunohistochemical staining was prominent in tumor microvessels as well as glial tumor cells. In areas of highly proliferating glial tumor cells, tracer uptake (SUVs) in the [F-18]Galacto-RGD PET images correlated with immunohistochemical alpha(v)beta(3) integrin expression of corresponding tumor samples. These data suggest that [F-18] Galacto-RGD PET successfully identifies alpha(v)beta(3) expression in patients with GBM and might be a promising tool for planning and monitoring individualized cancer therapies targeting this integrin. Neuro-Oncology 11, 861870, 2009 (Posted to Neuro-Oncology [serial online], Doc. D08-00188, April 28, 2009. URL http://neuro-oncology.dukejournals.org; DOI: 10.1215/15228517-2009-024)
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