Journal
NEURAL REGENERATION RESEARCH
Volume 9, Issue 12, Pages 1210-1216Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.135329
Keywords
nerve regeneration; autophagy; lysosome; autophagosome; neuron; cerebral ischemia; signaling pathway; apoptosis; necrosis; survival; NSFC grant; neural regeneration
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Funding
- National Natural Science Foundation of China [31171014, 31371065]
- Science and Technology Commission of Board of Health of Shanghai, China [20134125]
- Key Specialty (disease) Declaration of Pudong New Area's Health System
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Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.
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