Journal
NEURAL REGENERATION RESEARCH
Volume 9, Issue 18, Pages 1653-1656Publisher
SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES
DOI: 10.4103/1673-5374.141797
Keywords
spinal cord injury; Decorin; transforming growth factor-beta; scarring; chondroitin sulphate proteoglycan; matrix metalloproteases
Categories
Funding
- Wellcome Trust [092539/Z/10/Z]
- International Spinal Research Trust [STR103]
- National Institute for Health research (NIHR) Surgical Reconstruction and Microbiology Research Centre
- International Spinal Research Trust [STR103] Funding Source: researchfish
- Wellcome Trust [092539/Z/10/Z] Funding Source: Wellcome Trust
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The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical barrier to regenerating axons. Decorin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-fibrotic and anti-inflammatory and attenuates the formation and partial dissolution of established and chronic scars. Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system.
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