Journal
NEURAL REGENERATION RESEARCH
Volume 9, Issue 3, Pages 285-292Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.128225
Keywords
nerve regeneration; spinal cord injury; carbon nanotubes; amino functionalization; nerve growth factor; cytotoxicity; biological activity; dispersibility; PC12 cells; chick embryo dorsal root ganglion; NSFC grant; neural regeneration
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Funding
- National Natural Science Foundation of China [81160395]
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Carbon nanotubes can carry protein into cells to induce biological effects. Amino-functionalized carbon nanotubes are soluble and biocompatible, have high reactivity and low toxicity, and can help promote nerve cell growth. In this study, amino-functionalized ethylenediamine-treated multi-walled carbon nanotubes were used to prepare carbon nanotubes-nerve growth factor complexes by non-covalent grafting. The physicochemical properties, cytotoxicity to PC12 and chick embryo dorsal root ganglion, and biological activity of the carbon nanotubes-nerve growth factor complexes were investigated. The results showed that amino functionalization improved carbon nanotubes-nerve growth factor complex dispersibility, reduced their toxicity to PC12 cells, and promoted PC12 cell differentiation and chick embryo dorsal root ganglion.
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