Journal
NERVENARZT
Volume 83, Issue 6, Pages 714-+Publisher
SPRINGER
DOI: 10.1007/s00115-012-3479-8
Keywords
Guillain-Barre syndrome; Polyradiculoneuritis; Vaccination against influenza; Influenza infection; Influenza virus A/H1N1/2009
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Guillain-Barr, Syndrome (GBS) is an acquired, monophasic inflammatory polyradiculoneuritis of autoimmune origin, which occurs after infection and occasionally also after vaccination. Seasonal and pandemic influenza vaccines have in particular been implicated as triggers for GBS. However, a number of recent studies indicate that infection with influenza virus may also cause GBS. This review summarizes the epidemiological and experimental data of the association of GBS with exposure to influenza antigens by immunization (including vaccines against A/H1N1/2009) and infection. Vaccination against influenza is associated with a very low risk for the occurrence of GBS. In contrast infection with influenza may play a more important role as a triggering factor for GBS than previously assumed.
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