Journal
NEPHRON CLINICAL PRACTICE
Volume 127, Issue 1-4, Pages 42-45Publisher
KARGER
DOI: 10.1159/000363715
Keywords
Acute kidney injury; Biogenesis; Mitochondrial function; Mitophagy; Renal recovery
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Funding
- NIH UAB-UCSD O'Brien Center [P30 DK079337]
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Mitochondrial dysfunction within the tubular epithelium has been implicated in the pathogenesis of acute kidney injury. Inflammatory, ischemic, or toxic insults dysregulate mitochondrial dynamics, resulting in mitochondrial swelling, fission, and apoptosis. The coordinated processes of generating healthy mitochondria and clearing damaged organelles may contribute to the preservation and restoration of mitochondrial homeostasis. Emerging literature suggests that a master regulator of mitochondrial biogenesis, peroxisome proliferator-activated receptor-gamma-coactivator-1 alpha (PGC-1 alpha), is highly expressed in the tubular epithelium of the healthy kidney, and its induction during the post-injury period may contribute to functional recovery from acute kidney injury. (C) 2014 S. Karger AG, Basel
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