Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 28, Issue 11, Pages 2687-2697Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gft320
Keywords
ACE2; kidney disease; reninangiotensin system
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Funding
- NIDDK [1 R01 DK080089]
- Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation (ISCIII-FEDER) [PI11/01549]
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Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that degrades angiotensin (Ang) II to Ang-(17). ACE2 is highly expressed within the kidneys, it is largely localized in tubular epithelial cells and less prominently in glomerular epithelial cells and in the renal vasculature. ACE2 activity has been shown to be altered in diabetic kidney disease, hypertensive renal disease and in different models of kidney injury. There is often a dissociation between tubular and glomerular ACE2 expression, particularly in diabetic kidney disease where ACE2 expression is increased at the tubular level but decreased at the glomerular level. In this review, we will discuss alterations in circulating and renal ACE2 recently described in different renal pathologies and disease models as well as their possible significance.
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