Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 25, Issue 11, Pages 3773-3778Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfq268
Keywords
coronary artery calcification; kidney transplantation; vascular calcification
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Funding
- Fonds special de Recherche of the Universite catholique de Louvain
- European Union [FP6]
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Background. Coronary artery calcification (CAC) independently predicts cardiovascular events (CVE) in the general population. Whether this applies to renal transplant recipients (RTR) is unknown. This prospective study assessed the prognostic impact of CAC on CVE in RTR. Methods. We followed up a published cohort of 281 prevalent RTR. At baseline, 16- slice chest spiral computerized tomography scan was performed and classical as well as CKD- related risk factors were recorded. Major CVE (MCVE) was defined as cardiovascular death, myocardial infarction, stroke or transient ischaemic attack. All CVE (ACVE) included MCVE and revascularizations. Prognostic factors were assessed by univariate and multivariate Cox regression. Results. During 2.3 +/- 0.5 years of follow-up, 16 patients died from CV (n = 8) or non-CV causes (n = 8). Thirty-one RTR developed at least one CVE (first CVE cardiac in 15, peripheral in 12 and cerebrovascular in 4) for a total of 36 CVE. Thirty-month CV survival, MCVE-free survival and ACVE-free survival was 96.4, 93.9 and 87.9%, respectively. By multivariate analysis, the independent predictors of ACVE were CAC score (hazards ratios [HR] = 1.40 [1.12; 1.75] for a 2.72-fold increase in CAC, P < 0.003) and history of CVE (HR = 2.76 [1.21; 6.39], P < 0.02). Conclusion. Our study shows for the first time that CAC is a strong independent predictor of CVE in RTR.
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