Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 23, Issue 10, Pages 3353-3355Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfn401
Keywords
everolimus; pneumonitis; sirolimus; transplantation
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Inhibitors of mTOR (mammalian target of rapamycin) are immunosuppressants with less nephrotoxic potential than calcineurin inhibitors and antiproliferative effects, which are advantageous in the case of malignancy. However, a series of adverse events has been reported with the first-generation mTOR inhibitor sirolimus that includes hypersensitivity-like interstitial pneumonitis. To our knowledge, only one case of a pneumonitis associated with everolimus in a heart transplant patient has been reported, and it was related to elevated trough blood levels. We report herein the first case of a kidney graft recipient who developed everolimus-associated pneumonitis with normal trough blood levels that was completely reversed after drug withdrawal.
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