Journal
NEPHROLOGY
Volume 20, Issue 1, Pages 1-5Publisher
WILEY
DOI: 10.1111/nep.12342
Keywords
bioimpedance; fluid status; lung congestion; overhydration; peritoneal dialysis; ultrasound
Categories
Funding
- International Society of Nephrology and Kidney Research UK
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BackgroundBioimpedance spectroscopy (BIS), ultrasound lung comets (ULC) and serum biomarkers (N-terminal pro-brain natriuretic peptide, NT-proBNP) have all been used to assist clinicians to determine hydration status in dialysis patients. MethodsWe performed simultaneous BIS, ULC and NT-proBNP measurements in 27 peritoneal dialysis patients to determine the concordance of the three methods. ResultsPatients with evidence of increasing lung congestion (as determined by ultrasound) were more likely to be diabetic, have systolic hypertension and have higher NT-proBNP (r=0.65, P<0.0005). Although there was a trend for patients with high ULC to be overhydrated as determined by BIS, this did not reach statistical significance. Moreover, the correlation between BIS and NT-proBNP (though statistically significant at r=0.47, P<0.02) appeared to be weaker. ConclusionBIS and ULC may be complementary, providing different information, whereas BIS may be more specific to hydration. ULC and NT-proBNP may indicate left ventricular failure coexisting with overhydration. Summary at a Glance We assessed fluid status in 27 peritoneal dialysis patients using bioimpedance spectroscopy (BIS), lung ultrasound (ULC) and N-terminal pro-brain natriuretic peptide (NT-proBNP). BIS and ULC appear to be complementary, although BIS may be more specific for hydration status, whereas ULC and NT-proBNP appear to be more specific for left ventricular dysfunction with pulmonary fluid overload.
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