Journal
NEPHROLOGY
Volume 16, Issue 2, Pages 125-133Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1440-1797.2010.01414.x
Keywords
antibody specificity; crossmatching; flow cytometry; graft rejection; kidney transplantation; tissue
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Crossmatching of potential renal donors against potential renal transplant recipients has been performed for over 40 years and is a mandatory component of the transplant work-up process. However, gone are the days when all that was available was the T-cell complement-dependent cytotoxicity crossmatch. There are now many more options available for determining the likelihood of donor-specific antibody-mediated responses including flow crossmatching and the 'virtual' crossmatch. In addition, assays to determine the extent of sensitization of cell-mediated responses are being examined. This article builds an understanding of modern day crossmatch interpretation using a case-based approach in order to provide a framework for the general nephrologist to determine the likely immune consequences of a particular donor-recipient pairing.
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