Journal
SOFT MATTER
Volume 11, Issue 26, Pages 5346-5352Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sm00893j
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Funding
- Indiana University
- Graduate Training Program in Quantitative and Chemical Biology [T32GM109825]
- Sandia National Laboratories
- United States Department of Energy under DOE [DE-ACO4-94AL85000]
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We investigated the rotational dynamics of single microparticles during their internalization by macrophage cells. The microparticles used were triblock patchy particles that display two fluorescent patches on their two poles. The optical anisotropy made it possible to directly visualize and quantify the orientation and rotation of the particles. We show that particles exhibit a mixture of fast and slow rotation as they are uptaken by macrophages and transiently undergo directional rotation during their entry into the cell. The size of the particles and the surface presentation of ligands exerted a negligible influence on this heterogeneity of particle rotation.
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