Journal
NEONATOLOGY
Volume 105, Issue 2, Pages 136-141Publisher
KARGER
DOI: 10.1159/000356035
Keywords
Newborn; Infant; Trained immunity; Innate immunity
Categories
Funding
- Bill & Melinda Gates Foundation [OPPGH5284, OPP1035192]
- NIH [1R01AI100135-01, K08GM106143]
- Thrasher Research Fund
- Gerber Foundation
- Vanderbilt Department of Pediatrics (Turner-Hazinski Research Award)
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI100135] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [K08GM106143] Funding Source: NIH RePORTER
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The newborn and infant periods of early life are associated with heightened vulnerability to infection. Limited antigen exposure and distinct adaptive immune function compared to the adult places a greater burden on innate immunity for host defense to microbial challenge during this time. Trained immunity describes the phenomenon of augmented innate immune function following a stimulus that is not specific to the original stimulus. We review the concept of trained immunity in the context of the newborn's unique innate immune system function, the preclinical and clinical evidence that supports the tenet of innate immune memory in early life, and potential consequences of altered innate immune host responses. (C) 2013 S. Karger AG, Basel
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