Journal
NEONATOLOGY
Volume 96, Issue 3, Pages 137-149Publisher
KARGER
DOI: 10.1159/000209850
Keywords
CDH; Pulmonary hypoplasia; Transgenics; Nitrofen; Retinoids; Surgery
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Funding
- Canadian Institute of Health Research, Ottawa, Canada [MOP-77751]
- Erasmus MC fellowship, Rotterdam, The Netherlands
- Foundation 'Sophia Kinderziekenhuis', Rotterdam, The Netherlands
- Michael-Van Vloten Foundation, Rotterdam, The Netherlands
- De Drie Lichten' Foundation, Leiden, The Netherlands
- Trustfonds, Rotterdam, The Netherlands
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Congenital diaphragmatic hernia (CDH) occurs in 1 in 3,000 newborns. Mortality and morbidity are due to the amount of pulmonary hypoplasia (PH), the response on artificial ventilation and the presence of therapy-resistant pulmonary hypertension. The pathogenesis and etiology of CDH and its associated anomalies are still largely unknown despite all research efforts over the past years. Several animal models have been proposed to study CDH. In this review we compare surgical, pharmacological and transgenic models, and discuss their strengths and limitations to study PH. Copyright (C) 2009 S. Karger AG, Basel
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