Journal
SOFT MATTER
Volume 11, Issue 37, Pages 7241-7249Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sm01896j
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We propose a facile and robust carbohydrate-mediated method for the prevention of nanoparticle induced denaturation and aggregation of proteins. Using label-free plasmon-enhanced Raman spectroscopy measurements, the mechanistic principles of trehalose stabilization in a model protein-nanoparticle system are elucidated for the first time, facilitating its further application in diagnostic and therapeutic nanoplex development.
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