Related references
Note: Only part of the references are listed.Sensitisation of TRPV4 by PAR(2) is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase
Silvia Sostegni et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2015)
The epidemiology of osteoarthritis
Victoria L. Johnson et al.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2014)
Integrin α1β1 participates in chondrocyte transduction of osmotic stress
Christina L. Jablonski et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo
M. S. Grace et al.
BRITISH JOURNAL OF PHARMACOLOGY (2014)
Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations
Holly A. Leddy et al.
FASEB JOURNAL (2014)
In situ intracellular calcium oscillations in osteocytes in intact mouse long bones under dynamic mechanical loading
Da Jing et al.
FASEB JOURNAL (2014)
Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells
Xinying Jia et al.
FEBS LETTERS (2014)
A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1
Ferda Cevikbas et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)
Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4
Peishen Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Biomechanics and mechanobiology in functional tissue engineering
Farshid Guilak et al.
JOURNAL OF BIOMECHANICS (2014)
Effective Knock Down of Matrix Metalloproteinase-13 by an Intra-Articular Injection of Small Interfering RNA (siRNA) in a Murine Surgically-Induced Osteoarthritis Model
Ryuichiro Akagi et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2014)
TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor
Yong Chen et al.
PAIN (2014)
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage
Whasil Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading
Christopher J. O'Conor et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Patient-Derived Skeletal Dysplasia Induced Pluripotent Stem Cells Display Abnormal Chondrogenic Marker Expression and Regulation by BMP2 and TGFβ1
Biagio Saitta et al.
STEM CELLS AND DEVELOPMENT (2014)
Use of Cartilage Derived From Murine Induced Pluripotent Stem Cells for Osteoarthritis Drug Screening
Vincent P. Willard et al.
ARTHRITIS & RHEUMATOLOGY (2014)
Gene Expression Pattern of Cells From Inflamed and Normal Areas of Osteoarthritis Synovial Membrane
Cecile Lambert et al.
ARTHRITIS & RHEUMATOLOGY (2014)
Effects of cyclic equibiaxial mechanical stretch on α-BK and TRPV4 expression in equine chondrocytes
Ismail M. Hdud et al.
SPRINGERPLUS (2014)
TRPV4 channel activation improves the tensile properties of self-assembled articular cartilage constructs
Sriram V. Eleswarapu et al.
ACTA BIOMATERIALIA (2013)
Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis
E. S. Michael et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet
Christopher J. O'Conor et al.
ANNALS OF THE RHEUMATIC DISEASES (2013)
MicroRNA-203 up-regulates nitric oxide expression in temporomandibular joint chondrocytes via targeting TRPV4
Fang Hu et al.
ARCHIVES OF ORAL BIOLOGY (2013)
Osteoblastic differentiation enhances expression of TRPV4 that is required for calcium oscillation induced by mechanical force
Takafumi Suzuki et al.
BONE (2013)
TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk
B. C. J. van der Eerden et al.
BONE (2013)
Transient Receptor Potential Channels - Emerging Novel Drug Targets for the Treatment of Pain
Kinga Salat et al.
CURRENT MEDICINAL CHEMISTRY (2013)
Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix
Tonia L. Vincent
CURRENT OPINION IN PHARMACOLOGY (2013)
The puzzle of TRPV4 channelopathies
Bernd Nilius et al.
EMBO REPORTS (2013)
Protease-activated Receptor 2 (PAR2) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling
Daniel P. Poole et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Applied osmotic loading for promoting development of engineered cartilage
Sonal R. Sampat et al.
JOURNAL OF BIOMECHANICS (2013)
Contribution of TRPA1 as a Downstream Signal of Proteinase-Activated Receptor-2 to Pancreatic Pain
Yuka Terada et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2013)
Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion
Yong Chen et al.
PAIN (2013)
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling
Carlene Moore et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes
Ann K. Rosenthal et al.
ARTHRITIS RESEARCH & THERAPY (2013)
TRPV4-associated skeletal dysplasias
Gen Nishimura et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS (2012)
Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model
Anna K. Clark et al.
ARTHRITIS AND RHEUMATISM (2012)
Role of transient receptor potential vanilloid 4 in rat joint inflammation
Alexandre Denadai-Souza et al.
ARTHRITIS AND RHEUMATISM (2012)
Osteoarthritis: A disease of the joint as an organ
Richard F. Loeser et al.
ARTHRITIS AND RHEUMATISM (2012)
Proteases involved in cartilage matrix degradation in osteoarthritis
Linda Troeberg et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2012)
Activation of PAR2 receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint
F. A. Russell et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Expression of Transient Receptor Potential Vanilloid (TRPV) Channels in Different Passages of Articular Chondrocytes
Ismail M. Hdud et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass
Ritsuko Masuyama et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2012)
TRPV4 axonal neuropathy spectrum disorder
Meriel McEntagart
JOURNAL OF CLINICAL NEUROSCIENCE (2012)
A TRP that makes us feel hyper
Charles W. Bourque et al.
JOURNAL OF PHYSIOLOGY-LONDON (2012)
Correlation of protease-activated receptor-2 expression and synovitis in rheumatoid and osteoarthritis
Alistair G. Tindell et al.
RHEUMATOLOGY INTERNATIONAL (2012)
An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure
Kevin S. Thorneloe et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts
Alison M. Connor et al.
ARTHRITIS RESEARCH & THERAPY (2012)
The Involvement of TRP Channels in Bone Homeostasis
Liesbet Lieben et al.
Frontiers in Endocrinology (2012)
Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in Osteoarthritis
Olimpio Galasso et al.
ADVANCES IN ORTHOPEDICS (2012)
Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement
Erika H. Noss et al.
ARTHRITIS AND RHEUMATISM (2011)
Altered Expression of MicroRNA-203 in Rheumatoid Arthritis Synovial Fibroblasts and Its Role in Fibroblast Activation
Joanna Stanczyk et al.
ARTHRITIS AND RHEUMATISM (2011)
Biomechanical factors in osteoarthritis
Farshid Guilak
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2011)
TRPV4 Agonists and Antagonists
Fabien Vincent et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2011)
Acidosis environment promotes osteoclast formation by acting on the last phase of preosteoclast differentiation: A study to elucidate the action points of acidosis and search for putative target molecules
Kohtaro Kato et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
Fluid movement and joint capsule strains due to flexion in rabbit knees
William J. McCarty et al.
JOURNAL OF BIOMECHANICS (2011)
Thrombin-cleaved Osteopontin Levels in Synovial Fluid Correlate with Disease Severity of Knee Osteoarthritis
Masahiro Hasegawa et al.
JOURNAL OF RHEUMATOLOGY (2011)
Mutations in TRPV4 cause an inherited arthropathy of hands and feet
Shireen R. Lamande et al.
NATURE GENETICS (2011)
PROTEINASE-ACTIVATED RECEPTOR 2 SENSITIZES TRANSIENT RECEPTOR POTENTIAL VANILLOID 1, TRANSIENT RECEPTOR POTENTIAL VANILLOID 4, AND TRANSIENT RECEPTOR POTENTIAL ANKYRIN 1 IN PACLITAXEL-INDUCED NEUROPATHIC PAIN
Y. Chen et al.
NEUROSCIENCE (2011)
Dominant TRPV4 Mutations in Nonlethal and Lethal Metatropic Dysplasia
Natalia Camacho et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2010)
Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice
Fiore Cattaruzza et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)
Chondroprotective Role of the Osmotically Sensitive Ion Channel Transient Receptor Potential Vanilloid 4 Age- and Sex-Dependent Progression of Osteoarthritis in Trpv4-Deficient Mice
Andrea L. Clark et al.
ARTHRITIS AND RHEUMATISM (2010)
Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis
Urska Pozgan et al.
BIOLOGICAL CHEMISTRY (2010)
Involvement of transient receptor potential vanilloid 1 receptors in protease-activated receptor-2-induced joint inflammation and nociception
Zs. Helyes et al.
EUROPEAN JOURNAL OF PAIN (2010)
Mutations in the Gene Encoding the Calcium-Permeable Ion Channel TRPV4 Produce Spondylometaphyseal Dysplasia, Kozlowski Type and Metatropic Dysplasia
Deborah Krakow et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2009)
An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes
Yuka Itoh et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Functional Characterization of TRPV4 as an Osmotically Sensitive Ion Channel in Porcine Articular Chondrocytes
Mimi N. Phan et al.
ARTHRITIS AND RHEUMATISM (2009)
Global comparative transcriptome analysis of cartilage formation in vivo
Trevor L. Cameron et al.
BMC DEVELOPMENTAL BIOLOGY (2009)
The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli
Stuart M. Brierley et al.
GASTROENTEROLOGY (2009)
Thrombin-Cleaved Osteopontin in Synovial Fluid of Subjects with Rheumatoid Arthritis
Masahiro Hasegawa et al.
JOURNAL OF RHEUMATOLOGY (2009)
Tumor necrosis factor-alpha (TNF-α) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes
Mikhail Y. Kochukov et al.
MOLECULAR PAIN (2009)
A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia
Wei Tian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators
Hyun-Mi Choi et al.
ARTHRITIS RESEARCH & THERAPY (2009)
Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia
Walter E. B. Sipe et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
TRPV4-mediated calcium influx regulates terminal differentiation of Osteoclasts
Ritsuko Masuyama et al.
CELL METABOLISM (2008)
Proteinase-Activated Receptor-2 in the Skin: Receptor Expression, Activation and Function During Health and Disease
Anke Rattenholl et al.
DRUG NEWS & PERSPECTIVES (2008)
Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms
Nicolas Cenac et al.
GASTROENTEROLOGY (2008)
Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss
Fumitaka Mizoguchi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia
Matthew J. Rock et al.
NATURE GENETICS (2008)
Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells
Michael D. Horwich et al.
NATURE PROTOCOLS (2008)
Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation
Shuji Muramatsu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9
Kalpana Gupta et al.
ARTHRITIS AND RHEUMATISM (2007)
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
Yi Dai et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders
Trevor Bushell
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S
Enrico Weidauer et al.
BIOLOGICAL CHEMISTRY (2007)
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice
Andrew D. Grant et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Evaluation of protease-activated receptor 2 in murine models of arthritis
Nathalie Busso et al.
ARTHRITIS AND RHEUMATISM (2007)
Transient receptor potential channels as drug targets
Dayne Y. Okuhara et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2007)
Thermosensitive TRP ion channels mediate cytosolic calcium response in human synoviocytes
Mikhail Y. Kochukov et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
Cartilage breakdown in rheumatoid arthritis
FO Rannou et al.
JOINT BONE SPINE (2006)
Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon!
W Liedtke et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator
N Alessandri-Haber et al.
PAIN (2005)
In situ measurement of solute transport in the bone lacunar-canalicular system
LY Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis
R Goldbach-Mansky et al.
ANNALS OF THE RHEUMATIC DISEASES (2005)
Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2 as a potential therapeutic target
T Kanke et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2005)
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia
S Amadesi et al.
JOURNAL OF NEUROSCIENCE (2004)
Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain
Y Dai et al.
JOURNAL OF NEUROSCIENCE (2004)
Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans
W Liedtke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Abnormal osmotic regulation in trpv4-/- mice
W Liedtke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Hypo-osmotic stress induces calcium-dependent actin reorganization in articular chondrocytes
GR Erickson et al.
OSTEOARTHRITIS AND CARTILAGE (2003)
Reduction of cytokine-induced expression and activity of MMP-1 and MMP-13 by mechanical strain in MH7A rheumatoid synovial cells
HB Sun et al.
MATRIX BIOLOGY (2002)
Structure of a Cys25 -> Ser mutant of human cathepsin S
JP Turkenburg et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2002)
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway
N Vergnolle et al.
NATURE MEDICINE (2001)
Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis
Y Hashimoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Matrix metalloproteinase-1,-3,-13 and aggrecanase-1 and-2 are differentially expressed in experimental osteoarthritis
G Bluteau et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2001)
Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis
HK Ronday et al.
RHEUMATOLOGY (2001)
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
W Liedtke et al.
CELL (2000)
OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
R Strotmann et al.
NATURE CELL BIOLOGY (2000)
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
M Steinhoff et al.
NATURE MEDICINE (2000)
Share Paper
