Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 21, Issue 11, Pages 945-946Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2911
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Funding
- NIDA NIH HHS [R01 DA037150, R01 DA037755] Funding Source: Medline
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The fate of an mRNA is regulated by internal base modifications that generate the modified nucleotides N-6-methyladenosine, 5-methylcytosine and inosine. Three new studies show that yeast and human mRNAs also contain pseudouridine residues and that pseudouridylation is induced in various stress states, hinting at a new pathway for post-transcriptional control of mRNA.
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