Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 21, Issue 4, Pages 301-307Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2780
Keywords
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Funding
- US National Institutes of Health [GM095822]
- National Science Foundation [MCB0920082]
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E3 ligases carry out the final step in the ubiquitination cascade, catalyzing transfer of ubiquitin from an E2 enzyme to form a covalent bond with a substrate lysine. Three distinct classes of E3 ligases have been identified that stimulate transfer of ubiquitin and ubiquitin-like proteins through either a direct or an indirect mechanism. Only recently have the catalytic mechanisms of E3 ligases begun to be elucidated.
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