Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 20, Issue 3, Pages 259-266Publisher
NATURE RESEARCH
DOI: 10.1038/nsmb.2470
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Funding
- US National Institutes of Health [5U01 HG004274, U54 CA143862, R01 ES020116]
- Howard Hughes Medical Institute
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Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to DNA, and chemical modification of histones is a major means by which the cell modulates nucleosome mobility and turnover. Histone modifications are linked to essentially every cellular process requiring DNA access, including transcription, replication and repair. Here we consider properties of the major types of histone modification in the context of their associated biological processes to view them in light of the cellular mechanisms that regulate nucleosome dynamics.
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