Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 20, Issue 6, Pages 766-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2569
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Funding
- Danish Council for Independent Research [271-09-0187]
- European Molecular Biology Organization postdoctoral fellowship
- Swedish Research council
- Swedish Cancer Society
- integrated EU project European drug initiative on channels and transporters (EDICT)
- Singapore National Research Foundation Competitive Research Programme grant [NRF2008NRF-CRP002-067]
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Here we present two structures of the major facilitator (MFS) xylose transporter XylE from Escherichia coli in inward open and partially occluded inward open conformations. These structures provide key information about the transport cycle of XylE and the closely related human GLUT transporters. This is, to our knowledge, the first MFS transporter structure determined in more than one conformational state, which may establish XylE as an important MFS model protein.
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