Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 19, Issue 3, Pages 355-357Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2233
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Funding
- National Institute of Neurological Disorders and Stroke [NS064357]
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We report a structure of a trimeric glutamate transporter homolog from Pyrococcus horikoshii with two protomers in an inward facing state and the third in an intermediate conformation between the outward and inward facing states. The intermediate shows a cavity in the thinnest region of the transporter, which is potentially accessible to extracellular and cytoplasmic solutions. Our findings suggest a structural principle by which transport intermediates may mediate uncoupled permeation of polar solutes.
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