Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 19, Issue 1, Pages 5-7Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2220
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Oncogene-induced replication stress and DNA damage are among the hallmarks of cancer. A recent study explores how different levels of replication stress affect animal development and tumorigenesis, and how targeting of the replication stress-signaling pathway of ATR and Chk1 kinases can be exploited for selective killing of cancer cells.
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