Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 19, Issue 7, Pages 719-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2327
Keywords
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Funding
- Brown University [8P30GM103410]
- [R01GM095612-01]
- [NSF1020552]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1020552] Funding Source: National Science Foundation
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We present the first large-scale identification of lariats-the transient branched introns that are released as a byproduct of pre-mRNA splicing. The locations of the branchpoints in these introns provide insight into the early steps of splicing. From this data set, we have developed a comprehensive model of 3' splice-site selection, identified new mechanisms of alternative splicing and mapped the distribution of splicing factors around branchpoints.
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