Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 19, Issue 5, Pages 555-557Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2270
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Funding
- University of California, San Diego
- Howard Hughes Medical Institute
- Cell, Molecular and Genetics (CMG) Training Program
- US National Institutes of Health [T32GM007240]
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Group II introns are self-splicing catalytic RNAs that are thought to be ancestral to the spliceosome. Here we report the 3.65-angstrom crystal structure of the group II intron from Oceanobacillus iheyensis in the pre-catalytic state. The structure reveals the conformation of the 5' splice site in the catalytic core and represents the first structure of an intron prior to the first step of splicing.
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