Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 19, Issue 11, Pages 1061-1064Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2437
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Funding
- NCI NIH HHS [R01 CA151535] Funding Source: Medline
- NIAID NIH HHS [R01 AI044432] Funding Source: Medline
- NICHD NIH HHS [R01 HD065812] Funding Source: Medline
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TET and JBP proteins catalyze the oxidation of methylated C bases in the mammalian genome and of the methyl group of T bases in kinetoplastid genomes, respectively. A recent study in Nature Structural & Molecular Biology suggests a new function of 5-methylcytosine oxidation in regulating RNA polymerase II elongation rate that is reminiscent of that of base J in transcription termination in Leishmania.
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