Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 18, Issue 12, Pages 1432-1434Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2173
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Funding
- Fanconi Anaemia Research Fund
- Children's Leukaemia Trust
- Grants-in-Aid for Scientific Research [21390094] Funding Source: KAKEN
- Medical Research Council [MC_U105178811] Funding Source: researchfish
- MRC [MC_U105178811] Funding Source: UKRI
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Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway. These results define a fundamental role for the combined action of formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival.
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