4.5 Article

Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo

Justin Legleiter et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Heme proteins-Diversity in structural characteristics, function, and folding

Lorna J. Smith et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)

Article Biochemical Research Methods

Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences

Vinal V. Lakhani et al.

PLOS COMPUTATIONAL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Examining Polyglutamine Peptide Length: A Connection between Collapsed Conformations and Increased Aggregation

Robert H. Walters et al.

JOURNAL OF MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

Stephen Tam et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

Ashwani K. Thakur et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

Single homopolypeptide chains collapse into mechanically rigid conformations

Lorna Dougan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

The impact of ataxin-1-like histidine insertions on polyglutamine aggregation

Murali Jayaraman et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2009)

Article Multidisciplinary Sciences

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

Wei-Feng Xue et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence

Zoya Ignatova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Reconsidering the mechanism of polyglutamine peptide aggregation

Christine C. Lee et al.

BIOCHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Protein aggregation processes: In search of the mechanism

Carl Frieden

PROTEIN SCIENCE (2007)

Article Biochemistry & Molecular Biology

A toxic monomeric conformer of the polyglutamine protein

Yoshitaka Nagai et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Effects of chain length on the aggregation of model polyglutamine peptides: Molecular dynamics simulations

Alexander J. Marchut et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)

Article Multidisciplinary Sciences

Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions

Scott L. Crick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biochemistry & Molecular Biology

Analysis of molecular recognition features (MoRFs)

Amrita Mohan et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Article Multidisciplinary Sciences

Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins

Natalia Slepko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step

Andrew M. Ellisdon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Biochemistry & Molecular Biology

Characterizing the conformational ensemble of monomeric polyglutamine

XL Wang et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)

Article Biochemistry & Molecular Biology

Oligoproline effects on polyglutamine conformation and aggregation

A Bhattacharyya et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Review Biochemical Research Methods

Nucleation: The connections between equilibrium and kinetic behavior

Frank A. Ferrone

AMYLOID, PRIONS, AND OTHER PROTEIN AGGREGATES, PT B (2006)

Article Biochemistry & Molecular Biology

Polyglutamine is not all: The functional role of the AXH domain in the ataxin-1 protein

C de Chiara et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Polyglutamine homopolymers having 8-45 residues form slablike β-crystallite assemblies

D Sharma et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)

Article Multidisciplinary Sciences

Polyglutamine aggregation nucleation: Thermodynamics of a highly unfavorable protein folding reaction

AM Bhattacharyya et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Thermodynamics of Aβ(1-40) amyloid fibril elongation

B O'Nuallain et al.

BIOCHEMISTRY (2005)

Article Biochemical Research Methods

Molecular origin of polyglutamine aggregation in neurodegenerative diseases

SD Khare et al.

PLOS COMPUTATIONAL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Influence of the N-terminal domain on the aggregation properties of the prion protein

KN Frankenfield et al.

PROTEIN SCIENCE (2005)

Article Biochemistry & Molecular Biology

New model for crystalline polyglutamine assemblies and their connection with amyloid fibrils

P Sikorski et al.

BIOMACROMOLECULES (2005)

Article Biochemical Research Methods

Kinetic analysis of beta-amyloid fibril elongation

MJ Cannon et al.

ANALYTICAL BIOCHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Mechanism of prion propagation: Amyloid growth occurs by monomer addition

SR Collins et al.

PLOS BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

JL Wacker et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)

Article Multidisciplinary Sciences

Mutational analysis of the structural organization of polyglutamine aggregates

AK Thakur et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

MA Poirier et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

SM Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Amyloid-like features of polyglutamine aggregates and their assembly kinetics

SM Chen et al.

BIOCHEMISTRY (2002)

Review Biochemistry & Molecular Biology

Identification and characterization of key kinetic intermediates in amyloid β-protein fibrillogenesis

MD Kirkitadze et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

S Chen et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Solubilization and disaggregation of polyglutamine peptides

SM Chen et al.

PROTEIN SCIENCE (2001)