Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 18, Issue 3, Pages 277-U56Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1977
Keywords
-
Funding
- Ministry of Education, Science and Culture of Japan [18074006, 22570161, 16087207, 21227006]
- Grants-in-Aid for Scientific Research [21227006, 22570161, 18074006, 16087207] Funding Source: KAKEN
Ask authors/readers for more resources
The proteins that form the bacterial flagellum are translocated to its distal end through the central channel of the growing flagellum by the flagellar-specific protein export apparatus, a family of the type III protein secretion system. FliI and FliJ are soluble components of this apparatus. FliI is an ATPase that has extensive structural similarity to the alpha and beta subunits of FoF1-ATP synthase. FliJ is essential for export, but its function remains obscure. Here we show that the structure of FliJ derived from Salmonella enterica serovar Typhimurium is remarkably similar to that of the two-stranded alpha-helical coiled-coil part of the gamma subunit of FoF1-ATP synthase and that FliJ promotes the formation of FliI hexamer rings by binding to the center of the ring. These results suggest that the type III protein export system and F- and V-type ATPases share a similar mechanism and an evolutionary relationship.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available