Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 18, Issue 4, Pages 500-503Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2029
Keywords
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Funding
- Associazione Italiana per la Ricerca sul Cancro [4765]
- Hecksher Foundation for Children
- Byrne Fund
- US National Institutes for Health [P01CA94060, R01GM54668]
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Homologous recombination (also termed homology-directed repair, HDR) is a major pathway for the repair of DNA interstrand cross-links (ICLs) in mammalian cells. Cells from individuals with Fanconi anemia (FA) are characterized by extreme ICL sensitivity, but their reported defect in HDR is mild. Here we examined ICL-induced HDR using a GFP reporter and observed a profound defect in ICL-induced HDR in FA cells, but only when the reporter could replicate.
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