Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 17, Issue 9, Pages 1152-1153Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1892
Keywords
-
Funding
- Wellcome Trust Seeding Drug Discovery Initiative
- US Department of Defense Joint Science and Technology Office for Chemical and Biological Defense [HDTRA1-07-9-0002]
- Defense Threat Reduction Agency's Transformational Medical Technologies
Ask authors/readers for more resources
Quinolone antibacterials have been used to treat bacterial infections for over 40 years. A crystal structure of moxifloxacin in complex with Acinetobacter baumannii topoisomerase IV now shows the wedge-shaped quinolone stacking between base pairs at the DNA cleavage site and binding conserved residues in the DNA cleavage domain through chelation of a noncatalytic magnesium ion. This provides a molecular basis for the quinolone inhibition mechanism, resistance mutations and invariant quinolone antibacterial structural features.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available