Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 17, Issue 5, Pages 530-538Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1779
Keywords
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Funding
- US National Institutes of Health [U54GM074958, U01AI74497, AI11772, AI074497, U01AI174497]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI011772, R01AI011772, U01AI074497] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U54GM074958] Funding Source: NIH RePORTER
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The world is currently undergoing a pandemic caused by an H1N1 influenza A virus, the so-called 'swine flu'. The H5N1 ('bird flu') influenza A viruses, now circulating in Asia, Africa and Europe, are extremely virulent in humans, although they have not so far acquired the ability to transfer efficiently from human to human. These health concerns have spurred considerable interest in understanding the molecular biology of influenza A viruses. Recent structural studies of influenza A virus proteins (or fragments) help enhance our understanding of the molecular mechanisms of the viral proteins and the effects of drug resistance to improve drug design. The structures of domains of the influenza RNA-dependent RNA polymerase and the nonstructural NS1A protein provide opportunities for targeting these proteins to inhibit viral replication.
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