Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 17, Issue 2, Pages 238-240Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1768
Keywords
-
Funding
- Human Frontiers Science Program fellowship
- Terry Fox Foundation fellowship from the Canadian Cancer Society
- Canadian Institutes of Health Research
Ask authors/readers for more resources
GW182-family proteins are essential for microRNA-mediated translational repression and deadenylation in animal cells. Here we show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure of the complex. Mutations at the complex interface impair mRNA deadenylation in mammalian cell extracts, suggesting that the GW182-PABC interaction contributes to microRNA-mediated gene silencing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available