Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 17, Issue 10, Pages 1260-1262Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1904
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Funding
- Tobacco-Related Disease Research Program [17FT-0046]
- US National Institutes of Health [GM58015, CA92276]
- US Department of Defense [DAMD17-00-1-0187]
- Susan G. Komen Breast Cancer Foundation [BCTR0201259]
- University of California Davis Cancer Center
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BRCA2 is a tumor suppressor that functions in homologous recombination, a key genomic integrity pathway. BRCA2 interacts with RAD51, the central protein of recombination, which forms filaments on single-stranded DNA (ssDNA) to perform homology search and DNA strand invasion. We report the purification of full-length human BRCA2 and show that it binds to similar to 6 RAD51 molecules and promotes RAD51 binding to ssDNA coated by replication protein A (RPA), in a manner that is stimulated by DSS1.
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